IRF1 and eosinophilic esophagitis: For example, ABI3 (161 kb from rs12952581) and GATA3 have been linked to eosinophil counts and asthma32, respectively, as well as LRRC32, which encodes the eosinophilic esophagitis-associated TGF-β membrane binding protein GARP. In addition, IRF1 encodes a protein that activates genes involved in proinflammatory regulation and has been associated with childhood allergic asthma33, where it may also have sex-specific effects34.