Lamin A/C has been proposed as an iCAF marker, its upregulation may promote gene expression profiles, mediated through the PI3K/AKT/PTEN signaling pathway (Kong et al, 2012), that favor tumor–CAF interactions and CRC progression (Kong et al, 2012; Willis et al, 2008; Urciuoli et al, 2021). This evidence concerns the gene AKT1 and neoplasm.