IL6 and colorectal carcinoma: This observation is in line with studies that showed that Fn increased IL-6, IL-8 (CXCL8), and CXCL1 expressions in both human normal gingival fibroblast (Rath-Deschner et al, 2020) and CRC cells (Rubinstein et al, 2013; Casasanta et al, 2020; Rossano et al, 1993).