Contrary to our findings, studies by Hou et al. and Myakala K et al. demonstrated that reduced NAD+ levels mediate STING axis activation, inducing pro-inflammatory factor expression and cellular senescence, while NR supplementation alleviates this pro-inflammatory microenvironment and slows Alzheimer’s disease progression [53, 54]. The gene discussed is STING1; the disease is early-onset autosomal dominant Alzheimer disease.