During a median follow-up of 52 months, ischemic stroke (IS), transient ischemic attack (TIA), cardiovascular (CV) death, major bleeding, and a composite endpoint (defined as IS, TIA, or CV death) were recorded.<h4>Results</h4>43 patients (17.9%) were positive for ANA (mean 22.9 EU), including 20 (46.5%) with positive ACR/EULAR-aPL. This evidence concerns the gene BTG3 and ischemic stroke.