Instead, as previously reported in leukemia cells40, sorafenib rapidly inhibited phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E) in PC9 cells (Fig. 3A), as well as other NSCLC cells, including two different PDC lines (Fig. 3B and Supplementary Fig. 3B, C), and CRC cells (Supplementary Fig. 3D). This evidence concerns the gene EIF4E and non-small cell lung carcinoma.