Instead, as previously reported in leukemia cells40, sorafenib rapidly inhibited phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E) in PC9 cells (Fig. 3A), as well as other NSCLC cells, including two different PDC lines (Fig. 3B and Supplementary Fig. 3B, C), and CRC cells (Supplementary Fig. 3D). The gene discussed is EIF4E; the disease is colorectal carcinoma.