Except in oral squamous cell and colorectal cancer, where it is not overexpressed, S100A16 is upregulated in several tumor types, promoting increased cell proliferation, invasion, and metastasis through multiple molecular pathways, including PI3K-Akt, MAPK-ERK, JNK/p38, and EMT signaling [32]. This evidence concerns the gene S100A16 and colorectal cancer.