DKK1 and colorectal cancer: Of note, inhibition of Wnt(10b) signaling in chromosomally stable colorectal cancer cells (HCT116), either at the canonical (co)receptor level by DKK1 treatment, by knockout of the Wnt secretion factor EVI/WNTLESS (Augustin et al, 2017) or of the WNT10B ligand (Fig S1A) triggered increased microtubule growth rates in mitotic cells as determined by live-cell microscopy tracking of individual microtubule plus tips within mitotic spindles (Fig 1B and C, Video 1).