Our work revealed a yet unrecognized and unexpected function of Wnt10b signaling to protect cells from mitotic errors and chromosomal breaks in response to DNA replication stress, which is a major source for chromosomal instability (CIN) in human cancer (Zeman & Cimprich, 2014; Igarashi et al, 2024). The gene discussed is WNT10B; the disease is cervical squamous intraepithelial neoplasia.