Importantly, treatment of synchronized Wnt-inhibited or CIN+ cancer cells with low doses of Taxol just before mitosis (Fig 3E) was sufficient to restore normal microtubule growth rates and suppressed chromosome missegregation (Fig 3F and G), whereas treatment with DKK1 had no additional effect on microtubule dynamics and chromosome missegregation in CIN+ cancer cells (Fig S3A and B). Here, DKK1 is linked to cancer.