First, the majority of FDC antihypertensives were combinations of ACE inhibitors or ARBs plus thiazide diuretics,34 and ACE inhibitors and ARBs may be insufficient for improving hypertension control for NHB adults, possibly due to poorer medication adherence and/or differences in physiological pathways.37, 38, 39 The AHA/ACC guideline recommends initial antihypertensive treatment with a thiazide diuretic or CCBs for NHB adults. The gene discussed is ACE; the disease is Hypertension.