,15 Sustained antigenic and inflammatory stimulation in sepsis results in a significant reduction in the number and efficacy of T-cells due to apoptosis and high expression of suppressive immune checkpoint molecules (PD-1, Tim-3), which promotes immunosuppression and even leads to immune system collapse.11, 12, 13 The changes in T-cell subsets in sepsis patients have significant clinical predictive value: the reduction of the CD4+/CD8+ T-cell ratio in trauma patients directly correlates with the risk of sepsis and multiple organ dysfunction syndrome.8 The gene discussed is HAVCR2; the disease is Sepsis.