Contraindicated in ketoacidosis; back pain; cystitis; dizziness; dyslipidaemia; hypoglycaemia (in combination with insulin or sulfonylurea); increased risk of infection; prostatitis; skin reactions; urinary and vulvovaginal disorders.The treatment should be discontinued when pregnancy is detected, not recommended for the 2nd and 3rd trimester of pregnancy. This evidence concerns the gene INS and urogenital neoplasm.