IL-1 blockade is also indicated for treatment of AIDs, such as cryopyrin-associated periodic syndromes (CAPS), familial Mediterranean fever (FMF) [70], TNF receptor-associated periodic syndrome (TRAPS) and mevalonate kinase deficiency [70–72] and in HLH/MAS [18, 19]. This evidence concerns the gene IL1B and cryopyrin-associated periodic syndrome.