Coimmunoprecipitation (Co-IP) confirmed interactions between Flag-tagged AKR1B10 and hemagglutinin (HA)–tagged PPP2CA, as well as endogenous AKR1B10 and PPP2CA in CRC/GC cells, with colocalization observed primarily in the cytosol (Fig. 5, C to E, and fig. Here, AKR1B10 is linked to gastric cancer.