AKR1B10 and colorectal carcinoma: Notably, tumors derived from MC38-shAkr1b8 cells exhibited a notable increase in liver metastasis in both nonobese diabetic (NOD)–severe combined immunodeficient (SCID) and C57BL/6 mouse models (Fig. 3, C and D), suggesting that AKR1B10 and Akr1b8 suppress CRC metastasis via cell-intrinsic mechanisms.