In vivo, AKR1B10WT, but not AKR1B10K125L, attenuated liver metastasis of AKR1B10-deficient CRC cells in the intrasplenic injection mouse model (Fig. 6, L and M), nor did AKR1B10K125L reduce c-Myc and ITGB8 expression within liver metastatic lesions (Fig. 6, N and O). The gene discussed is ITGB8; the disease is colorectal carcinoma.