Furthermore, spatial dissociation of nuclear SFPQ and FUS, which normally form a high–molecular weight (HMW) complex, causes increased four-repeat tau isoform expression, which, in turn, leads to frontotemporal dementia (FTD)–like phenotypes in mice (12) and neurodegeneration in human cortical neurons (13). The gene discussed is FUS; the disease is frontotemporal dementia.