Our findings are also supported by a recent preprint from Zeng et al. (62), demonstrating that knockdown of the ALS-associated TDP-43 protein shifts poly(A) site usage from proximal to distal in the SFPQ gene, consistent with the shift from wtSFPQ to altSFPQ expression, which we have identified across models derived from patients with familial and sporadic ALS. Here, TARDBP is linked to amyotrophic lateral sclerosis.