HMGCR and prostate carcinoma: Lemos et al. (37) treated androgen-dependent prostate cancer cells (LNCaP) with BAY-3827 and reported several down-regulated genes involved in lipid metabolism that we also observed were down-regulated by BAY-3827 treatment in MK-8722–stimulated control primary hepatocytes, namely LIPE, PFKFB2, and HMGCR.