TNF and Sepsis: Crosstalk between inflammation and coagulation is considered crucial in the pathogenesis of sepsis, whereby inflammatory cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor-α (TNFα) induce the activation of coagulation, whereas protease-activated receptors (PARs) are activated by coagulation proteases to initiate signaling and subsequent cytokine production [11].