Increased aspartate transaminase (AST) (AOR: 4.39; 95% CI: 1.75–11.01), thrombocytopenia (AOR: 6.04; 95% CI: 2.41–15.12), and prolonged prothrombin time (PT) (AOR: 3.40; 95% CI: 1.36–8.51) were independent predictors of DIC in sepsis patients. Here, F2 is linked to Sepsis.