PLA2R1 and nephrotic syndrome: At present, PMN is believed to be related to the autoimmune response associated with podocyte antigens, the most common of which is the M-type phospholipase A2 receptor (PLA2R), concurrently, emerging scholarship demonstrates that non-invasive serological profiling can discriminate PLA2R-associated membranous nephropathy from both non-PLA2R-related MN and other nephrotic syndromes with high fidelity [1,2].