IGFBP1 and cancer: Participants PB1, PB3, PP4, PP6, PE8, PP12, PP13, PE15, PP16, PP19, PM21, PB23, PM24, PB25, PE26, PE27, and PB28 reported that excessive alcohol consumption can cause long-term harm to an individual’s health due to the associated risks, including liver, heart, neurological, and kidney problems, increased susceptibility to various types of cancer, alcoholic coma, and premature death.