The combination of three parameters: NLR+CEA+CA19-9 (SN 76.5%, SP 88.9%, AUC = 0.886; 95% confidence interval: 0.838–0.933, P = 0.000) showed the best diagnostic efficacy and the authors concluded that this combination may be used to screen and diagnose BC (Zou et al. 2022). The gene discussed is CEACAM5; the disease is breast cancer.