The authors identified a panel of autoantigens, including lectin, galactoside-binding, soluble 3 (LGALS3; SN 63%, AUC = 0.687), prohibitin 2 (PHB2; SN 43%, AUC = 0.583), mucin 1 (MUC1; SN 46%, AUC = 0.563) and glycerol kinase 2 (GK2; SN 46%, AUC = 0.608) that in combination with CA15-3 improved sensitivity, specificity and overall survival in the diagnosis of BC (stage T1N0M0). This evidence concerns the gene PHB2 and breast cancer.