Lactobacillus, increased with progressive stages of neoplasia, was inversely associated with TRIM50, an E3 ubiquitin ligase that inhibits the Myc signaling pathway and is downregulated in gastric cancer.22Actinomyces relative abundance was associated with the greatest number of changes in the tissue transcriptome, with altered expression of >500 genes. The gene discussed is TRIM50; the disease is gastric cancer.