We observed upregulation of LAIR2, which is postulated to represent a marker of T cell exhaustion in tumors34 and perhaps reflects changes to the immune microenvironment in BE-associated neoplasia.17,18 Recent transcriptomic analyses from 16 EAC resections simulating bulk RNA-Seq using single cell sequencing data found that BE tissue without dysplasia clustered with dysplasia and EAC.35 Only when analyses were stratified by cell type were gene expression differences apparent across stages of neoplasia. This evidence concerns the gene LAIR2 and neoplasm.