Although genes associated with immunomodulation were not among the top genes showing changes after fibulin-3 knockdown (as expected, given other predominant functions of fibulin-3 on tumor progression), gene ontology analysis revealed increased expression of genes associated with inflammatory, IFN-γ, and IFN-α responses (Fig. 2D), suggesting that fibulin-3 downregulates these genes in GSCs. This evidence concerns the gene EFEMP1 and neoplasm.