Fibulin-3 can be inhibited with a function-blocking antibody, mAb428.2, which prevents this protein from activating NF-κB signaling in GBM and PI3K/Akt signaling in mesothelioma, resulting in the extended survival of mice carrying fibulin-3–expressing tumors (26, 27). The gene discussed is EFEMP1; the disease is glioblastoma.