Some ad patients also have transactive response DNA‐binding protein of 43 kDa (TDP‐43) inclusions on histology, with phosphorylated TDP‐43 pathology being shown in approximately 57% of ad patients [17] and limbic age‐related TDP‐43 encephalopathy (LATE‐NC) found in around 50% of ad patients [18]. Here, TARDBP is linked to nevus comedonicus syndrome.