sB7‐H1 exhibited an increasing trend in patients with clinical symptoms such as xerostomia, xerophthalmia, decayed tooth, fatigue, arthralgia, and glandular swelling, as well as in those with high IgG levels and positivity for anti‐SSB/La, anti‐SSA/Ro60, and anti‐SSA/Ro52. The gene discussed is CALR; the disease is Keratoconjunctivitis sicca.