The present study demonstrates that the values of ALT ≥ 26 IU/L in boys and ≥22 IU/L in girls, as proposed by NASPGHAN for the screening of NAFLD in normal‐weight children and adolescents, are superimposable to that observed in our population of youths with OW/OB with respect to MASLD. This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.