AKT1 and nonpapillary renal cell carcinoma: Figure 11A shows that in LILRB3-knockdown ccRCC cells, the expression levels of genes related to the PI3K/AKT/mTOR pathway and CD274 were downregulated. As depicted in Figure 11B, compared to cells transfected with control vectors, ccRCC cells with reduced LILRB3 expression exhibited significantly decreased protein levels of PI3K, p-PI3K, AKT, p-AKT, mTOR, p-mTOR, and PD-L1.