Histopathological evaluation of the resected lesion confirmed a combined hepatocellular–cholangiocarcinoma (cHCC-CC) composed of both moderately differentiated (grade 2) cholangiocarcinoma (CK7+, CK19+, and CD34+ sinusoidal vessels) and well-differentiated (grade 1) hepatocellular carcinoma (glypican-3 focal+ and TTF-1+) components. Here, GPC3 is linked to cholangiocarcinoma.