In HIV/AIDS, severe CD4+ T-cell depletion (<50 cells/μL) further cripples EBV-specific immunity, enabling uncontrolled viral replication and molecular mimicry between EBV nuclear antigens (e.g., EBNA-1) and erythrocyte surface proteins (e.g., Band 3) [10,13,14,15]. This evidence concerns the gene CD4 and AIDS.