In ClinVar database, CTNNB1 p.(Ser37Phe) is reported as a “Pathogenic/Likely pathogenic” variant in multiple tumor types (e.g., prostate, hepatocellular, gastric, ovary, and melanoma) and as a somatic oncogenic event in pilomatrixoma (Variation ID: 17586; last accessed on 1 February 2023). This evidence concerns the gene CTNNB1 and pilomatrixoma.