Hematoxylin–eosin and single-immunohistochemical staining (Figure 1m–t) demonstrated that the clusters in IgE-mediated AD were composed mainly of T cells (CD3+, CD4+, and CD8+ cells), DCs (CD11c+, IgE+, CD206+, and CD207+ cells), and macrophages (CD68+ and CD206+ cells). Here, IGHE is linked to Alzheimer disease.