CD4 and Alzheimer disease: Acanthosis was milder than in AD; spongiotic vesicles and superficial crusting of the epidermis occurred more frequently; infiltration of CD4+ cells and IDECs (CD206+ and/or CD11c+ cells) was less prominent compared to those of CD8+ cells and CD207+ LCs in the spongiotic epidermis; IDECs rarely formed aggregates, and epidermal DC clusters were not observed; few IL-13+ cells were observed in the spongiotic epidermis; and IgE-expressing cells were restricted to a subset of MCs in the dermis.