In our previous analysis, as in APT-induced AD-like lesions, it was demonstrated that in lichenified eczema, IgE-expressing IDECs that had captured HDM antigens infiltrated and accumulated in the spongiosis epidermis together with CD4+ cells in approximately 60% of patients with IgE-mediated AD and HDM allergy (same patients in the present study) [1,10]. This evidence concerns the gene CD4 and allergic disease.