This discrepancy may reflect differences in analytical methodologies, but it may also suggest that in IgE-mediated AD, IDECs infiltrating the spongiotic epidermis may no longer express significant levels of IL-12p70, which induces Th1 responses, despite capturing, internalizing, and presenting antigens to T-lymphocytes within these lesions. The gene discussed is IGHE; the disease is Alzheimer disease.