Indeed, our previous study demonstrated that IgE-expressing IDECs coexisting with HDM antigens accumulated within the spongiotic epidermis of skin lesions in four (cases 1, 2, 5, and 6: 66.7%) of the six IgE-mediated AD patients sensitized to HDM, and these IDECs tended to localize in regions of CD4+ T-cell infiltration [10]. Here, CD4 is linked to Alzheimer disease.