IGHE and allergic disease: Interestingly, in the six cases of IgE-mediated AD with HDM allergy analyzed in the present study, no IL-12p70 expression was detected in IDECs within the spongiosis epidermis or in IDECs forming epidermal DC clusters, despite previous confirmation that these IDECs had captured HDM antigens in four of the six cases (cases 1, 2, 5, and 6) [1,10].