Compared to IgE-mediated AD, spongiosis formation in NE showed a more intense inflammatory response, with marked infiltration of T cells (CD3+, CD4+, and CD8+ cells) and IDECs (CD206+ and/or CD11c+ cells) across a broader area of acanthotic epidermis with spongiotic changes. The gene discussed is ITGAX; the disease is Alzheimer disease.