Ιn a previous comprehensive review, we highlighted the multifaceted and often contradictory roles of PROX1 in neoplasia [14], emphasizing its regulation of pathways like Wnt/β-catenin, Notch, and VEGF-C/VEGFR-3 [15], which are critical to lymphangiogenesis, tumor progression, and immune evasion [16,17,18]. This evidence concerns the gene FLT4 and neoplasm.