CPVT type 1 (CPVT1), the most prevalent form, is caused by autosomal dominant mutations in RYR2, which encodes the cardiac ryanodine receptor 2—an essential calcium-release channel located on the sarcoplasmic reticulum [89]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia 1.