Our present results rather demonstrate that the new genetic variants of SMAD3, REL, LY96, IRAK1, TREX1, CD40, REL, SAMD9L and ITGA2B in SSc-ILD do exist in Kazakh population and that further research is needed to reveal if the alterations are unique for Kazakh nation. This evidence concerns the gene LY96 and interstitial lung disease.