Our present results rather demonstrate that the new genetic variants of SMAD3, REL, LY96, IRAK1, TREX1, CD40, REL, SAMD9L and ITGA2B in SSc-ILD do exist in Kazakh population and that further research is needed to reveal if the alterations are unique for Kazakh nation. The gene discussed is IRAK1; the disease is systemic sclerosis.