Early studies in NF1- and NF2-associated tumours have revealed abnormal patterns of DNA methylation, dysregulation of expression, and disruptions in chromatin regulation, suggesting that these changes may influence tumour suppressor gene function, Schwann cell behaviour, and the tumour microenvironment, ultimately contributing to the clinical heterogeneity observed in these disorders [30,31]. The gene discussed is NF1; the disease is neoplasm.