For the SP1 gene in LC, overexpression (according to our reanalysis of the GEO datasets) corresponds to a decrease (relative to control) in the DNA methylation level of the regulatory region of the gene (our new experimental data), and conversely, in HD, underexpression (data from our reanalysis of the GEO datasets) corresponds to an increase in the DNA methylation level (our new experimental data). The gene discussed is SP1; the disease is Huntington disease.