In patients with LC, there was a statistically significant—with correction for multiple comparisons—upregulation of the genes PSEN1 (padj = 0.002), NFKB1 (padj = 0.023), SP1 (padj = 0.0004), and BDNF (padj = 0.014) and downregulation of genes BCL11B (padj = 2.27 × 10−16), MLH1 (padj = 0.006) (GSE42834), and GLS2 (p = 0.045) (GSE12771/GPL60102). The gene discussed is BDNF; the disease is laryngotracheoesophageal cleft.