BM-MSCs alleviate liver cirrhosis by modulating the Creb3l1/long noncoding(lnc)RNA Kcnq1ot1/miR-374-3p/Follistatin-related protein 1 (Fstl1) signaling pathway.55 Recent findings suggested that miR-146a, a known suppressor of CREB3l1, is present in the BM-MSC secretome and may explain alleviation of liver cirrhosis by BM-MSCs.70 Schematics of the role of MSCs in liver fibrosis are illustrated in Figure 6A. Here, CREB3L1 is linked to Hepatic fibrosis.