While RET and BRAF fusions have been documented in TKI-resistant cases (Schrock et al., 2018; Wang et al., 2022), chromosomal rearrangements involving NTRK1 are rare in NSCLC, with a frequency ranging from 0.1% to 3.3% (Liu et al., 2022). This evidence concerns the gene BRAF and non-small cell lung carcinoma.