In addition to Th2 cells, group 2 innate lymphoid cells (ILC2s) significantly contribute to T2 inflammation; they rapidly respond to epithelial-derived cytokines (IL-25, IL-33, and TSLP) and produce IL-5 and IL-13 (Wallrapp et al., 2018), promoting further eosinophilia and tissue responses in parallel to Th2-driven adaptive immunity. The gene discussed is IL5; the disease is Increased total eosinophil count.