GPX4 and gastric cancer: In the study, we demonstrated that, (1) CA sensitized GC cells to cisplatin treatment; (2) Ferroptosis inhibition damaged the effect of CA as a chemosensitizer; (3) CA triggered GC cell ferroptosis by repressing Gpx4 expression; (4) High Gpx4 expression predicted a poor OS and DFS in patients with GC; and (5) CA increased cisplatin sensitivity by regulating Gpx4.