In addition, non-histone lactylation is also involved in HCC progression; for example, the latest research has shown that non-histone ABCF1-K430 lactylation promotes the malignant progression of HCC through transcriptional activation of the HIF1 signaling pathway, but its relationship with drug resistance phenotype still needs to be further confirmed[68]. This evidence concerns the gene HIF1A and hepatocellular carcinoma.