In breast cancer, KCNK1 upregulates LDHA activity and promotes H3K18la enrichment, which in turn increases LDHA gene expression and downstream oncogenes, forming a KCNK1–LDHA–H3K18la–LDHA positive feedback loop that drives metastasis and chemoresistance[23,24]. The gene discussed is KCNK1; the disease is breast cancer.