IL6ST and glioblastoma: Designing an exercise strategy that targets gp130-mediated signaling could have therapeutic application in brain tumors like glioblastoma by influencing endothelial-mediated actions (102), and decreasing neuronal loss and hyperinflammation (103), evidenced by the increase of gp130 by running exercise, which suppresses the STAT3 signaling to improve mitochondrial quality (104).