Designing an exercise strategy that targets gp130-mediated signaling could have therapeutic application in brain tumors like glioblastoma by influencing endothelial-mediated actions (102), and decreasing neuronal loss and hyperinflammation (103), evidenced by the increase of gp130 by running exercise, which suppresses the STAT3 signaling to improve mitochondrial quality (104). The gene discussed is STAT3; the disease is glioblastoma.