Moreover, finding the association between exercise training and different protocols on single-nucleotide polymorphisms (SNPs), such as rs2228145 SNP, could modify the expression of sIl-6R, which might extend the half-life of IL-6 from minutes to hours; thus, it can transiently increase its effects from its production site to distant regions of the brain to produce systemic effects to target neurodegenerative diseases (27). The gene discussed is IL6; the disease is neurodegenerative disease.