This could suggest a higher frequency of CD19+ B cells in the peripheral blood of lymphoma donors, although DLBCL donors tend to have similar or lower B cell counts compared to healthy donors (Hou et al, 2021 and Geuna et al, 2014), it could also suggest that malignant CD19+ B cells produce more EV than healthy CD19+ B cells. This evidence concerns the gene CD19 and diffuse large B-cell lymphoma.