NFE2L2 and diabetes mellitus: An imbalance in the redox status of cells produces lipid peroxidation, protein oxidation, DNA injury and activates various signal pathways such as the NF-κB and Nrf2/ARE signaling, all resulting in insulin resistance, pancreatic β-cell dysfunction, and various micro- and macrovascular complications of DM such as neuropathy, nephropathy, and hepatic damage (3).