HMOX1 and myocardial ischemia: Additionally, a study found that a 1:1 ratio of dashes and HSYA positively influenced cardio protection against myocardial ischemia by modulating the protein kinase B (Akt)/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway (15).