KDM5B and Transcription factor AP-2 gamma (AP-2γ, it regulates cell proliferation, cell cycle, and apoptosis, and participates in the occurrence of a variety of cancers (Xing et al., 2022)) cooperate with Myc (overexpression of which can lead to tumorigenesis) to inhibit the cell cycle inhibitor p21, and the ectopic expression of KDM5B can also promote the EMT of cancer cells (Cui et al., 2017). The gene discussed is KDM5B; the disease is cancer.