Reg3A/G (Reg3G, a mouse homologue of human Reg3A) is a gene associated with pancreatic cancer (especially pancreatic ductal adenocarcinoma PDAC), and P. gingivalis can upregulate the expression of Reg3A/G through its LPS, suggesting that it may be an important target for the prevention of periodontal disease-associated pancreatic cancers (as shown in Figure 5) (Hiraki et al., 2020). This evidence concerns the gene REG3A and periodontal disorder.