First, throughout the EMT (epithelial-mesenchymal transition) process, cancer cells often undergo molecular events, e.g., decreased levels of epithelial markers (E-cadherin, cytokeratins), decreased levels of mesenchymal markers (N-cadherin, vimentin), and they acquire a high migratory and invasive capacity through the increase in EMT-related transcription factors (TFs) (Snail, Slug, TWIST, ZEB). Here, CDH2 is linked to cancer.