However, other reports showed that Decorin overexpression can inhibit hypertension-induced cardiac fibrosis and hypertrophy and improved cardiac function (Yan et al., 2009), and can further inhibit TGF-β pathway and its pro-fibrotic effects on the failing human heart (Yan et al., 2009; Jahanyar et al., 2007), which makes it a potential candidate in HCM pathogenesis. Here, DCN is linked to cardiac hypertrophy.