TGFB1 and Myocardial fibrosis: MCP1-driven pro-inflammatory signaling may accentuate cardiomyocyte death and can mediate fibrosis upon recruiting monocytes and macrophages that secrete mediators, such as TGF-β (Hanna and Frangogiannis, 2020), a key driver in myocardial fibrosis in HCM (Ibrahim et al., 2020a).