LUM and heart failure: Other ECM proteins also contribute to fibrosis and hypertrophy in HCM; Lumican, identified through proteomic analyses, correlates with fibrosis severity and left atrial enlargement, and has been proposed as a marker of advanced fibrosis (Rixon et al., 2023) TNC is associated with inflammation-driven HCM and adverse outcomes, with serum levels offering prognostic value in heart failure (Kitaoka et al., 2012; Kitaoka et al., 2010; Matthia et al., 2022).