VEGFA and ischemia: In hypertrophied CMs, LN was thought to contribute to alterations in sarcolemmal properties (Oliviéro et al., 2000), and its deficiency can lead to malformation in the myocardial microvasculature and subsequent ischemia, represented in elevated levels of hypoxia-inducible factor 1α (Hif1α) and vascular endothelial growth factor A (VEGFA) transcripts (Wang et al., 2006).