Of interest, a recent study has shown that TIMP1 deficiency have significantly reduced myocardial fibrosis via meditating an association between CD63 (cell surface receptor for TIMP1) and integrin β1 on CFs, leading to de novo collagen synthesis, reducing myocardial fibrosis, independent from MMPs (Takawale et al., 2017). This evidence concerns the gene CD177 and Myocardial fibrosis.