AKT1 and colorectal cancer: In addition, long‐term low‐dose Cd exposure promoted the invasive and metastatic ability of colorectal cancer cells through the unique activation of the EGFR signaling pathway, which is evidenced by persistent EGFR signaling and activation of Akt/mTOR cascade, whereas blocking EGFR eliminated the promotion of Cd on the metastasis of colorectal cancer cells to the liver [179].