The results showed that in rapidly progressing ALS patients, the ratio of Th17 cells (proinflammatory) to Treg cells (anti‐inflammatory) was significantly increased and positively correlated with disease progression rate; the ratio of effector CD8 T cells to naïve CD8 T cells were higher in the rapid progression group, with the ratio positively correlated with progression speed and the proportion of CD16highCD56low mature NK cells was higher in the rapid progression group. This evidence concerns the gene CD8A and amyotrophic lateral sclerosis.