ScRNA‐seq and computational ligand‐target predictions (NicheNet28) [314] analysis in microglia revealed that perivascular SPP1 induced microglial phagocytosis in the AD mice hippocampus, and loss of SPP1 expression prevented synaptic loss, suggesting a functional role of SPP1 in the crosstalk between perivascular cells and microglia in AD. This evidence concerns the gene SPP1 and Alzheimer disease.