APOE4 is the strongest genetic risk factor for late‐onset AD and has been reported to exacerbate AD‐related pathologies [130, 131], including amyloid‐β (Aβ) plaques, tau tangles, neurodegeneration, and neuroinflammation [132, 133, 134, 135, 136]. The gene discussed is APOE; the disease is Alzheimer disease.