The metabolic reprogramming of TECs during AKI is regulated by an intricate signaling network involving AMP-activated protein kinase (AMPK), mechanistic target of rapamycin complex 1 (mTORC1), sirtuins (SIRTs), PPARα, PGC-1α, and hypoxia-inducible factor-1 alpha (HIF-1α). The gene discussed is PPARA; the disease is acute kidney injury.