They should be considered when selecting the most appropriate therapeutic option for treating oral mucosal melanoma.10 Other factors with a relevant influence on oral melanoma survival are the type of melanoma, with amelanotic melanomas having the worst prognosis probably due to diagnostic delay32 or the overexpression of certain genes such as the BAP1 gene that regulates cell differentiation, division, and death.34 The BAP1 gene encodes a tumor suppressor protein that plays a pivotal role in the pathogenesis of uveal melanoma. This evidence concerns the gene BAP1 and melanoma.