While the 15q11.2 microdeletion is strongly associated with neurodevelopmental and epileptic features, the extensive multisystem involvement observed in this patient, such as early-onset schizencephaly, type 2 diabetes, asthma, and CFTR-related findings, suggests the contribution of additional genetic, environmental, or epigenetic factors. The gene discussed is CFTR; the disease is schizencephaly.