Interestingly, GSE and vitamin C can enhance IFN-γ production, indicating a clear shift toward a Th1 response, which activates the cellular immune compartment and facilitates cancer cell destruction through mechanisms that are independent of natural killer (NK) natural killer T (NKT) cells, but dependent on CD8+ T-cell recognition via MHC class I presentation (129, 130). Here, IFNG is linked to cancer.