Evodiamine, a natural product, inhibits NLRP3 inflammasome assembly to activate cellular autophagy, attenuates experimental DSS-induced colitis injury, and suppresses NLRP3 inflammasome by inhibiting apoptosis-associated speckle-like protein oligomerization and caspase-1 activity in macrophages (144). This evidence concerns the gene NLRP3 and colitis.