Membrane-associated LRRK2 (associated with TAB2) leads to the inactivation of Beclin-1 and inhibition of autophagy, and both lymphoblastoid cells from control patients carrying a high-risk allele of LRRK2 and dendritic cells from CD patients exhibit elevated LRRK2 expression, leading to increased Dectin-1-mediated NF-κB activation and pro-inflammatory cytokine responses, resulting in more severe colitis (89). The gene discussed is LRRK2; the disease is colitis.